A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Ken Cadwell; John Y. Liu; Sarah L. Brown; Hiroyuki Miyoshi; Joy Loh; Jochen K. Lennerz; Chieko Kishi; Wumesh Kc; Javier A. Carrero; Steven Hunt; Christian D. Stone; Elizabeth M. Brunt; Ramnik J. Xavier; Barry P. Sleckman; Ellen Li; Noboru Mizushima; Thaddeus S. Stappenbeck; Herbert W. Virgin

doi:10.1038/NATURE07416

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Ken Cadwell
, John Y. Liu
, Sarah L. Brown
, Hiroyuki Miyoshi
, Joy Loh
, Jochen K. Lennerz
, Chieko Kishi
, Wumesh Kc
, Javier A. Carrero
, Steven Hunt
, Christian D. Stone
, Elizabeth M. Brunt
, Ramnik J. Xavier
, Barry P. Sleckman
, Ellen Li
, Noboru Mizushima
, Thaddeus S. Stappenbeck
, Herbert W. Virgin

Department of Pathology and Immunology,,
Tokyo Medical and Dental University
Department of Surgery,,
Department of Medicine,,
Harvard University
Washington University in St. Louis

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Nature
Volume	456
Issue number	7219
DOIs	https://doi.org/10.1038/NATURE07416
State	Published - Nov 13 2008
Externally published	Yes

Disciplines

Immunology and Infectious Disease
Biology
Oncology

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Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., Stone, C. D., Brunt, E. M., Xavier, R. J., Sleckman, B. P., Li, E., Mizushima, N., Stappenbeck, T. S., & Virgin, H. W. (2008). A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature, 456(7219). https://doi.org/10.1038/NATURE07416

Cadwell, K, Liu, JY, Brown, SL, Miyoshi, H, Loh, J, Lennerz, JK, Kishi, C, Kc, W, Carrero, JA, Hunt, S, Stone, CD, Brunt, EM, Xavier, RJ, Sleckman, BP, Li, E, Mizushima, N, Stappenbeck, TS & Virgin, HW 2008, 'A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells', Nature, vol. 456, no. 7219. https://doi.org/10.1038/NATURE07416

@article{4c083fd50a9f46e688c41267a20215d4,

title = "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells",

author = "Ken Cadwell and Liu, \{John Y.\} and Brown, \{Sarah L.\} and Hiroyuki Miyoshi and Joy Loh and Lennerz, \{Jochen K.\} and Chieko Kishi and Wumesh Kc and Carrero, \{Javier A.\} and Steven Hunt and Stone, \{Christian D.\} and Brunt, \{Elizabeth M.\} and Xavier, \{Ramnik J.\} and Sleckman, \{Barry P.\} and Ellen Li and Noboru Mizushima and Stappenbeck, \{Thaddeus S.\} and Virgin, \{Herbert W.\}",

note = "Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes to intestinal biology or Crohn's disease pathogenesis.",

year = "2008",

month = nov,

day = "13",

doi = "10.1038/NATURE07416",

language = "American English",

volume = "456",

journal = "Nature",

number = "7219",

}

TY - JOUR

T1 - A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

AU - Cadwell, Ken

AU - Liu, John Y.

AU - Brown, Sarah L.

AU - Miyoshi, Hiroyuki

AU - Loh, Joy

AU - Lennerz, Jochen K.

AU - Kishi, Chieko

AU - Kc, Wumesh

AU - Carrero, Javier A.

AU - Hunt, Steven

AU - Stone, Christian D.

AU - Brunt, Elizabeth M.

AU - Xavier, Ramnik J.

AU - Sleckman, Barry P.

AU - Li, Ellen

AU - Mizushima, Noboru

AU - Stappenbeck, Thaddeus S.

AU - Virgin, Herbert W.

N1 - Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes to intestinal biology or Crohn's disease pathogenesis.

PY - 2008/11/13

Y1 - 2008/11/13

UR - http://ui.adsabs.harvard.edu/abs/2008Natur.456..259C/abstract

U2 - 10.1038/NATURE07416

DO - 10.1038/NATURE07416

M3 - Article

VL - 456

JO - Nature

JF - Nature

IS - 7219

ER -

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

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