Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)

Tara K. Gregory; Jesus G. Berdeja; Krina K. Patel; Syed Abbas Ali; Adam D. Cohen; Caitlin Costello; Eric M. Ostertag; Nishan de Silva; Devon J. Shedlock; Michelle Resler; Matthew A. Spear; Robert Z. Orlowski

doi:10.1158/1538-7445.AM2018-CT130

Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)

Tara K. Gregory
, Jesus G. Berdeja
, Krina K. Patel
, Syed Abbas Ali
, Adam D. Cohen
, Caitlin Costello
, Eric M. Ostertag
, Nishan de Silva
, Devon J. Shedlock
, Michelle Resler
, Matthew A. Spear
, Robert Z. Orlowski

Colorado Blood Cancer Institute, Denver, CO;
Tennessee Oncology, San Diego, CA;
University of Texas MD Anderson Cancer Center
Johns Hopkins University
University of Pennsylvania
University of California, San Diego
POSEIDA, San Diego, CA.

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Cancer Research
Volume	78
DOIs	https://doi.org/10.1158/1538-7445.AM2018-CT130
State	Published - Jul 1 2018
Externally published	Yes

Disciplines

Medicine and Health Sciences
Oncology

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Gregory, T. K., Berdeja, J. G., Patel, K. K., Ali, S. A., Cohen, A. D., Costello, C., Ostertag, E. M., de Silva, N., Shedlock, D. J., Resler, M., Spear, M. A., & Orlowski, R. Z. (2018). Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM). Cancer Research, 78. https://doi.org/10.1158/1538-7445.AM2018-CT130

@article{3a59ff0c45004255b0667eaafabd2381,

title = "Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)",

author = "Gregory, \{Tara K.\} and Berdeja, \{Jesus G.\} and Patel, \{Krina K.\} and Ali, \{Syed Abbas\} and Cohen, \{Adam D.\} and Caitlin Costello and Ostertag, \{Eric M.\} and \{de Silva\}, Nishan and Shedlock, \{Devon J.\} and Michelle Resler and Spear, \{Matthew A.\} and Orlowski, \{Robert Z.\}",

note = "Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL Background: P-BCMA-101 is a novel chimeric antigen receptor (CAR)-T cell therapy designed to increase efficacy while minimizing toxicity through reduced immunogenicity, lack of tonic signaling, a safety switch, high purity (\&gt95\% CAR+) and a Tscm phenotype (Tscm are long-lived lymphocyte stem cells that appear to gradually differentiate into effectors, improving efficacy, durability and safety of a CAR-T therapeutic).",

year = "2018",

month = jul,

day = "1",

doi = "10.1158/1538-7445.AM2018-CT130",

language = "American English",

volume = "78",

journal = "Cancer Research",

issn = "1538-7445",

publisher = "American Association for Cancer Research",

}

TY - JOUR

T1 - Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)

AU - Gregory, Tara K.

AU - Berdeja, Jesus G.

AU - Patel, Krina K.

AU - Ali, Syed Abbas

AU - Cohen, Adam D.

AU - Costello, Caitlin

AU - Ostertag, Eric M.

AU - de Silva, Nishan

AU - Shedlock, Devon J.

AU - Resler, Michelle

AU - Spear, Matthew A.

AU - Orlowski, Robert Z.

N1 - Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL Background: P-BCMA-101 is a novel chimeric antigen receptor (CAR)-T cell therapy designed to increase efficacy while minimizing toxicity through reduced immunogenicity, lack of tonic signaling, a safety switch, high purity (&gt95% CAR+) and a Tscm phenotype (Tscm are long-lived lymphocyte stem cells that appear to gradually differentiate into effectors, improving efficacy, durability and safety of a CAR-T therapeutic).

PY - 2018/7/1

Y1 - 2018/7/1

UR - https://cancerres.aacrjournals.org/content/78/13_Supplement/CT130

U2 - 10.1158/1538-7445.AM2018-CT130

DO - 10.1158/1538-7445.AM2018-CT130

M3 - Article

SN - 1538-7445

VL - 78

JO - Cancer Research

JF - Cancer Research

ER -

Abstract CT130: Clinical trial of P-BCMA-101 T stem cell memory (Tscm) CAR-T cells in relapsed/refractory (r/r) multiple myeloma (MM)

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