Association of Effective Regurgitation Orifice Area to Left Ventricular End-Diastolic Volume Ratio With Transcatheter Mitral Valve Repair Outcomes: A Secondary Analysis of the COAPT Trial.

TY - JOUR

T1 - Association of Effective Regurgitation Orifice Area to Left Ventricular End-Diastolic Volume Ratio With Transcatheter Mitral Valve Repair Outcomes: A Secondary Analysis of the COAPT Trial.

AU - Lindenfeld, JoAnn

AU - Abraham, William T

AU - Grayburn, Paul A

AU - Kar, Saibal

AU - Asch, Federico M

AU - Lim, D Scott

AU - Nie, Hong

AU - Singhal, Pooja

AU - Sundareswaran, Kartik S

AU - Weissman, Neil J

AU - Mack, Michael J

AU - Stone, Gregg W

N1 - Importance Transcatheter mitral valve repair (TMVr) plus maximally tolerated guideline-directed medical therapy (GDMT) reduced heart failure (HF) hospitalizations (HFHs) and all-cause mortality (ACM) in symptomatic patients with HF and secondary mitral regurgitation (SMR) compared with GDMT alone in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) trial but not in a similar trial, Multicenter Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR), possibly because the degree of SMR relative to the left ventricular end-diastolic volume index (LVEDVi) was substantially lower.

PY - 2021/4/1

Y1 - 2021/4/1

UR - https://europepmc.org/article/MED/33533873

U2 - 10.1001/JAMACARDIO.2020.7200

DO - 10.1001/JAMACARDIO.2020.7200

M3 - Article

SN - 2380-6591

VL - 6

JO - JAMA Cardiology

JF - JAMA Cardiology

IS - 4

ER -