Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma

Gauthier L Stepman; Jaya Sanapati; Debra Angelo; Johnathan Frunzi

Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma

Gauthier L Stepman
, Jaya Sanapati
, Debra Angelo
, Johnathan Frunzi

HCA Florida Trinity Hospital

HCA Healthcare

Research output: Contribution to journal › Article › peer-review

Abstract

Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.

Original language	American English
Journal	Neurology
State	Published - Dec 15 2020

Keywords

cryptococcus
cryptococcal meningoencephalitis
encephalitis
meningoencephalitis

Disciplines

Bacterial Infections and Mycoses
Infectious Disease
Internal Medicine
Neurology

Access to Document

https://doi.org/10.7759/cureus.12094

Cite this

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title = "Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma",

abstract = " Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.",

keywords = "cryptococcus, cryptococcal meningoencephalitis, encephalitis, meningoencephalitis",

author = "Stepman, \{Gauthier L\} and Jaya Sanapati and Debra Angelo and Johnathan Frunzi",

note = "Stepman G, Sanapati J, Dabb K, et al. Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma. Cureus. 2020 Dec 14;12(12):e12094. doi:10.7759/cureus.12094",

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T1 - Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma

AU - Stepman, Gauthier L

AU - Sanapati, Jaya

AU - Angelo, Debra

AU - Frunzi, Johnathan

N1 - Stepman G, Sanapati J, Dabb K, et al. Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma. Cureus. 2020 Dec 14;12(12):e12094. doi:10.7759/cureus.12094

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.

AB - Cryptococcosis is a fungal infection that mostly affects immunocompromised patients. Diagnosis is based on the detection of cryptococcal antigen in the cerebrospinal fluid (CSF) or serum. Antifungal resistance is emerging, making treatment difficult and long. We report a case of cryptococcosis in a patient with multiple myeloma, years after undergoing a bone marrow transplant. Symptoms were mild, and imaging studies were nonspecific. CSF analysis revealed positive cryptococcal antigen. The patient was started on the standard three-phase antifungal therapy and recovered.

KW - cryptococcus

KW - cryptococcal meningoencephalitis

KW - encephalitis

KW - meningoencephalitis

UR - https://scholarlycommons.hcahealthcare.com/neurology/31

UR - https://doi.org/10.7759/cureus.12094

M3 - Article

JO - Neurology

JF - Neurology

ER -

Cryptococcal Meningoencephalitis 10 Years After Bone Marrow Transplant in a Patient With Multiple Myeloma

Abstract

Keywords

Disciplines

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