Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells

Nicholas Farrell; Lawrence F Povirk; Yojana Dange; Gerald DeMasters; Mona S Gupta; Glenda Kohlhagen; Qasim A Khan; Yves Pommier; David A Gewirtz; Gerald A. Demasters

doi:10.1016/J.BCP.2004.05.023

Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells

Nicholas Farrell
, Lawrence F Povirk
, Yojana Dange
, Gerald DeMasters
, Mona S Gupta
, Glenda Kohlhagen
, Qasim A Khan
, Yves Pommier
, David A Gewirtz
, Gerald A. Demasters

Virginia Commonwealth University
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochemical Pharmacology
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/J.BCP.2004.05.023
State	Published - Sep 1 2004

Disciplines

Molecular Biology
Immunology and Infectious Disease
Biology

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Farrell, N., Povirk, L. F., Dange, Y., DeMasters, G., Gupta, M. S., Kohlhagen, G., Khan, Q. A., Pommier, Y., Gewirtz, D. A., & Demasters, G. A. (2004). Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochemical Pharmacology, 68(5). https://doi.org/10.1016/J.BCP.2004.05.023

Farrell, N, Povirk, LF, Dange, Y, DeMasters, G, Gupta, MS, Kohlhagen, G, Khan, QA, Pommier, Y, Gewirtz, DA & Demasters, GA 2004, 'Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells', Biochemical Pharmacology, vol. 68, no. 5. https://doi.org/10.1016/J.BCP.2004.05.023

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title = "Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells",

author = "Nicholas Farrell and Povirk, \{Lawrence F\} and Yojana Dange and Gerald DeMasters and Gupta, \{Mona S\} and Glenda Kohlhagen and Khan, \{Qasim A\} and Yves Pommier and Gewirtz, \{David A\} and Demasters, \{Gerald A.\}",

note = "Cisplatin, cis-[PtCl2(NH3)2], is commonly utilized in various combination chemotherapy protocols for the treatment of both ovarian and breast cancer while the corresponding trans isomer is therapeutically inactive. This work describes efforts to elucidate the cellular mechanism of action of a novel ...",

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T1 - Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells

AU - Farrell, Nicholas

AU - Povirk, Lawrence F

AU - Dange, Yojana

AU - DeMasters, Gerald

AU - Gupta, Mona S

AU - Kohlhagen, Glenda

AU - Khan, Qasim A

AU - Pommier, Yves

AU - Gewirtz, David A

AU - Demasters, Gerald A.

N1 - Cisplatin, cis-[PtCl2(NH3)2], is commonly utilized in various combination chemotherapy protocols for the treatment of both ovarian and breast cancer while the corresponding trans isomer is therapeutically inactive. This work describes efforts to elucidate the cellular mechanism of action of a novel ...

PY - 2004/9/1

Y1 - 2004/9/1

UR - http://www.ncbi.nlm.nih.gov/pubmed/15294448

U2 - 10.1016/J.BCP.2004.05.023

DO - 10.1016/J.BCP.2004.05.023

M3 - Article

VL - 68

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 5

ER -

Cytotoxicity, DNA strand breakage and DNA–protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells

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