Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

Jean-Louis Vincent; Bruno Francois; Igor Zabolotskikh; Mradul Kumar Daga; Jean-Baptiste Lascarrou; Mikhail Y. Kirov; Ville Pettila; Xavier Wittebole; Ferhat Meziani; Emmanuelle Mercier; Suzana M. Lobo; Philip S. Barie; Mark Crowther; Charles T. Esmon; Jawed Fareed; Satoshi Gando; Kenneth J. Gorelick; Marcel Levi; Jean-Paul Mira; Steven M. Opal; Joseph Parrillo; Joseph Parrillo; James A. Russell; Hidehiko Saito; Kazuhisa Tsuruta; Takumi Sakai; David Fineberg; Romina Bertuzzi; Rinaldo Bellomo; Marianne Chapman; David Ernest; Jason Fletcher; Craig French; John Gowardman; Yahya Shehabi; Bala Venkatesh; James Walsham; Sanjiv Vij; Didier Chochrad; Jacques Creteur; Jacques Devriendt; Alain-Michel Dive; Thierry Dugernier; Frederic Foret; Eric Hoste; Philippe Jorens; Marc Simon; Herbert Spapen; Fernando Dias; Kenneth E. Krell

doi:10.1001/JAMA.2019.5358

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

Jean-Louis Vincent
, Bruno Francois
, Igor Zabolotskikh
, Mradul Kumar Daga
, Jean-Baptiste Lascarrou
, Mikhail Y. Kirov
, Ville Pettila
, Xavier Wittebole
, Ferhat Meziani
, Emmanuelle Mercier
, Suzana M. Lobo
, Philip S. Barie
, Mark Crowther
, Charles T. Esmon
, Jawed Fareed
, Satoshi Gando
, Kenneth J. Gorelick
, Marcel Levi
, Jean-Paul Mira
, Steven M. Opal

Joseph Parrillo, Joseph Parrillo, James A. Russell, Hidehiko Saito, Kazuhisa Tsuruta, Takumi Sakai, David Fineberg, Romina Bertuzzi, Rinaldo Bellomo, Marianne Chapman, David Ernest, Jason Fletcher, Craig French, John Gowardman, Yahya Shehabi, Bala Venkatesh, James Walsham, Sanjiv Vij, Didier Chochrad, Jacques Creteur, Jacques Devriendt, Alain-Michel Dive, Thierry Dugernier, Frederic Foret, Eric Hoste, Philippe Jorens, Marc Simon, Herbert Spapen, Fernando Dias, Kenneth E. Krell

Universite Libre de Bruxelles
French Institute of Health and Medical Research
Kuban State Medical University
Maulana Azad Medical College
University of Helsinki
Université catholique de Louvain
University of Strasbourg
Hospital de Base
Cornell University
St Joseph Hospital
Oklahoma Medical Research Foundation
Loyola University Medical Center
University College London
Paris Descartes University
Rhode Island Hospital
Rutgers University
Hackensack University Medical Center
St. Paul's Hospital

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	JAMA
Volume	321
Issue number	20
DOIs	https://doi.org/10.1001/JAMA.2019.5358
State	Published - May 28 2019

Disciplines

Medicine and Health Sciences
Internal Medicine

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Vincent, J.-L., Francois, B., Zabolotskikh, I., Daga, M. K., Lascarrou, J.-B., Kirov, M. Y., Pettila, V., Wittebole, X., Meziani, F., Mercier, E., Lobo, S. M., Barie, P. S., Crowther, M., Esmon, C. T., Fareed, J., Gando, S., Gorelick, K. J., Levi, M., Mira, J.-P., ... Krell, K. E. (2019). Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial. JAMA, 321(20). https://doi.org/10.1001/JAMA.2019.5358

Vincent, J-L, Francois, B, Zabolotskikh, I, Daga, MK, Lascarrou, J-B, Kirov, MY, Pettila, V, Wittebole, X, Meziani, F, Mercier, E, Lobo, SM, Barie, PS, Crowther, M, Esmon, CT, Fareed, J, Gando, S, Gorelick, KJ, Levi, M, Mira, J-P, Opal, SM, Parrillo, J, Parrillo, J, Russell, JA, Saito, H, Tsuruta, K, Sakai, T, Fineberg, D, Bertuzzi, R, Bellomo, R, Chapman, M, Ernest, D, Fletcher, J, French, C, Gowardman, J, Shehabi, Y, Venkatesh, B, Walsham, J, Vij, S, Chochrad, D, Creteur, J, Devriendt, J, Dive, A-M, Dugernier, T, Foret, F, Hoste, E, Jorens, P, Simon, M, Spapen, H, Dias, F & Krell, KE 2019, 'Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.', JAMA, vol. 321, no. 20. https://doi.org/10.1001/JAMA.2019.5358

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title = "Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.",

author = "Jean-Louis Vincent and Bruno Francois and Igor Zabolotskikh and Daga, \{Mradul Kumar\} and Jean-Baptiste Lascarrou and Kirov, \{Mikhail Y.\} and Ville Pettila and Xavier Wittebole and Ferhat Meziani and Emmanuelle Mercier and Lobo, \{Suzana M.\} and Barie, \{Philip S.\} and Mark Crowther and Esmon, \{Charles T.\} and Jawed Fareed and Satoshi Gando and Gorelick, \{Kenneth J.\} and Marcel Levi and Jean-Paul Mira and Opal, \{Steven M.\} and Joseph Parrillo and Joseph Parrillo and Russell, \{James A.\} and Hidehiko Saito and Kazuhisa Tsuruta and Takumi Sakai and David Fineberg and Romina Bertuzzi and Rinaldo Bellomo and Marianne Chapman and David Ernest and Jason Fletcher and Craig French and John Gowardman and Yahya Shehabi and Bala Venkatesh and James Walsham and Sanjiv Vij and Didier Chochrad and Jacques Creteur and Jacques Devriendt and Alain-Michel Dive and Thierry Dugernier and Frederic Foret and Eric Hoste and Philippe Jorens and Marc Simon and Herbert Spapen and Fernando Dias and Krell, \{Kenneth E.\}",

year = "2019",

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doi = "10.1001/JAMA.2019.5358",

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T1 - Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

AU - Vincent, Jean-Louis

AU - Francois, Bruno

AU - Zabolotskikh, Igor

AU - Daga, Mradul Kumar

AU - Lascarrou, Jean-Baptiste

AU - Kirov, Mikhail Y.

AU - Pettila, Ville

AU - Wittebole, Xavier

AU - Meziani, Ferhat

AU - Mercier, Emmanuelle

AU - Lobo, Suzana M.

AU - Barie, Philip S.

AU - Crowther, Mark

AU - Esmon, Charles T.

AU - Fareed, Jawed

AU - Gando, Satoshi

AU - Gorelick, Kenneth J.

AU - Levi, Marcel

AU - Mira, Jean-Paul

AU - Opal, Steven M.

AU - Parrillo, Joseph

AU - Russell, James A.

AU - Saito, Hidehiko

AU - Tsuruta, Kazuhisa

AU - Sakai, Takumi

AU - Fineberg, David

AU - Bertuzzi, Romina

AU - Bellomo, Rinaldo

AU - Chapman, Marianne

AU - Ernest, David

AU - Fletcher, Jason

AU - French, Craig

AU - Gowardman, John

AU - Shehabi, Yahya

AU - Venkatesh, Bala

AU - Walsham, James

AU - Vij, Sanjiv

AU - Chochrad, Didier

AU - Creteur, Jacques

AU - Devriendt, Jacques

AU - Dive, Alain-Michel

AU - Dugernier, Thierry

AU - Foret, Frederic

AU - Hoste, Eric

AU - Jorens, Philippe

AU - Simon, Marc

AU - Spapen, Herbert

AU - Dias, Fernando

AU - Krell, Kenneth E.

PY - 2019/5/28

Y1 - 2019/5/28

UR - https://jamanetwork.com/journals/jama/articlepdf/2733995/jama_vincent_2019_oi_190044.pdf

U2 - 10.1001/JAMA.2019.5358

DO - 10.1001/JAMA.2019.5358

M3 - Article

SN - 1538-3598

VL - 321

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JF - JAMA

IS - 20

ER -

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

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