Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review

Mohammad F Shaikh; William F Morano; John Lee; Elizabeth Gleeson; Blake D Babcock; Josef Michl; Ehsan Sarafraz-Yazdi; Matthew R Pincus; Wilbur B Bowne

Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review

Mohammad F Shaikh
, William F Morano
, John Lee
, Elizabeth Gleeson
, Blake D Babcock
, Josef Michl
, Ehsan Sarafraz-Yazdi
, Matthew R Pincus
, Wilbur B Bowne

Drexel University
SUNY Downstate Medical Center

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Annals of Clinical and Laboratory Science
Volume	46
Issue number	6
State	Published - Dec 1 2016
Externally published	Yes

Disciplines

Oncology

Cite this

@article{3df6134dc99e47f498ab612903d2434f,

title = "Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review",

author = "Shaikh, \{Mohammad F\} and Morano, \{William F\} and John Lee and Elizabeth Gleeson and Babcock, \{Blake D\} and Josef Michl and Ehsan Sarafraz-Yazdi and Pincus, \{Matthew R\} and Bowne, \{Wilbur B\}",

note = "The mouse/murine protein, MDM2, and its human homolog, HDM2, are important negative regulators of the p53 tumor suppressor protein. In normal, untransformed cells, MDM2 levels are tightly regulated to control expression of p53 and apoptosis. Conversely, MDM2 expression appears inherently higher in multiple types of cancer cells, thereby supporting its role as a suppressor of p53 pro-apoptotic activity.",

year = "2016",

month = dec,

day = "1",

language = "American English",

volume = "46",

journal = "Annals of Clinical and Laboratory Science",

issn = "1550-8080",

number = "6",

}

TY - JOUR

T1 - Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review

AU - Shaikh, Mohammad F

AU - Morano, William F

AU - Lee, John

AU - Gleeson, Elizabeth

AU - Babcock, Blake D

AU - Michl, Josef

AU - Sarafraz-Yazdi, Ehsan

AU - Pincus, Matthew R

AU - Bowne, Wilbur B

N1 - The mouse/murine protein, MDM2, and its human homolog, HDM2, are important negative regulators of the p53 tumor suppressor protein. In normal, untransformed cells, MDM2 levels are tightly regulated to control expression of p53 and apoptosis. Conversely, MDM2 expression appears inherently higher in multiple types of cancer cells, thereby supporting its role as a suppressor of p53 pro-apoptotic activity.

PY - 2016/12/1

Y1 - 2016/12/1

UR - http://europepmc.org/abstract/MED/27993876

M3 - Article

SN - 1550-8080

VL - 46

JO - Annals of Clinical and Laboratory Science

JF - Annals of Clinical and Laboratory Science

IS - 6

ER -

Emerging Role of MDM2 as Target for Anti-Cancer Therapy: A Review

Disciplines

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Cite this