Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.

Joshua M. Mares; Lisa S. Foley; Marshall T. Bell; Daine T. Bennett; Kirsten A. Freeman; Xianzhong Meng; Michael J. Weyant; Joseph C. Cleveland; David A. Fullerton; Ferenc Puskas; Thomas Brett Reece

doi:10.1016/J.JTCVS.2014.11.011

Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.

Joshua M. Mares
, Lisa S. Foley
, Marshall T. Bell
, Daine T. Bennett
, Kirsten A. Freeman
, Xianzhong Meng
, Michael J. Weyant
, Joseph C. Cleveland
, David A. Fullerton
, Ferenc Puskas
, Thomas Brett Reece

University of Colorado Boulder

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	The Journal of Thoracic and Cardiovascular Surgery
Volume	149
Issue number	3
DOIs	https://doi.org/10.1016/J.JTCVS.2014.11.011
State	Published - Mar 1 2015
Externally published	Yes

Disciplines

Endocrinology
Medicine and Health Sciences
Anesthesiology
Internal Medicine

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10.1016/J.JTCVS.2014.11.011License: Unspecified

Cite this

Mares, J. M., Foley, L. S., Bell, M. T., Bennett, D. T., Freeman, K. A., Meng, X., Weyant, M. J., Cleveland, J. C., Fullerton, D. A., Puskas, F., & Reece, T. B. (2015). Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. The Journal of Thoracic and Cardiovascular Surgery, 149(3). https://doi.org/10.1016/J.JTCVS.2014.11.011

Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. / Mares, Joshua M.; Foley, Lisa S.; Bell, Marshall T. et al.
In: The Journal of Thoracic and Cardiovascular Surgery, Vol. 149, No. 3, 01.03.2015.

Research output: Contribution to journal › Article › peer-review

Mares, JM, Foley, LS, Bell, MT, Bennett, DT, Freeman, KA, Meng, X, Weyant, MJ, Cleveland, JC, Fullerton, DA, Puskas, F & Reece, TB 2015, 'Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.', The Journal of Thoracic and Cardiovascular Surgery, vol. 149, no. 3. https://doi.org/10.1016/J.JTCVS.2014.11.011

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title = "Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.",

author = "Mares, \{Joshua M.\} and Foley, \{Lisa S.\} and Bell, \{Marshall T.\} and Bennett, \{Daine T.\} and Freeman, \{Kirsten A.\} and Xianzhong Meng and Weyant, \{Michael J.\} and Cleveland, \{Joseph C.\} and Fullerton, \{David A.\} and Ferenc Puskas and Reece, \{Thomas Brett\}",

note = "Paraplegia remains a devastating complication of complex aortic surgery. Erythropoietin (EPO) has been shown to prevent paraplegia after ischemia reperfusion, but the protective mechanism remains poorly described in the spinal cord. We hypothesized that EPO induces the CREB (cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury.",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/J.JTCVS.2014.11.011",

language = "American English",

volume = "149",

journal = "The Journal of Thoracic and Cardiovascular Surgery",

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TY - JOUR

T1 - Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.

AU - Mares, Joshua M.

AU - Foley, Lisa S.

AU - Bell, Marshall T.

AU - Bennett, Daine T.

AU - Freeman, Kirsten A.

AU - Meng, Xianzhong

AU - Weyant, Michael J.

AU - Cleveland, Joseph C.

AU - Fullerton, David A.

AU - Puskas, Ferenc

AU - Reece, Thomas Brett

N1 - Paraplegia remains a devastating complication of complex aortic surgery. Erythropoietin (EPO) has been shown to prevent paraplegia after ischemia reperfusion, but the protective mechanism remains poorly described in the spinal cord. We hypothesized that EPO induces the CREB (cAMP [adenosine 3′5′ cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury.

PY - 2015/3/1

Y1 - 2015/3/1

UR - http://www.ncbi.nlm.nih.gov/pubmed/25500291

U2 - 10.1016/J.JTCVS.2014.11.011

DO - 10.1016/J.JTCVS.2014.11.011

M3 - Article

VL - 149

JO - The Journal of Thoracic and Cardiovascular Surgery

JF - The Journal of Thoracic and Cardiovascular Surgery

IS - 3

ER -

Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury.

Disciplines

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