Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

Michael Costante; Lionel Biggemann; Yonas Alamneh; Iswarduth Soojhawon; Radley Short; Savita Nigam; Gregory Garcia; Bhupendra P. Doctor; Manojkumar Valiyaveettil; Madhusoodana P. Nambiar

doi:10.1016/J.TIV.2011.11.006

Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

Michael Costante
, Lionel Biggemann
, Yonas Alamneh
, Iswarduth Soojhawon
, Radley Short
, Savita Nigam
, Gregory Garcia
, Bhupendra P. Doctor
, Manojkumar Valiyaveettil
, Madhusoodana P. Nambiar

Walter Reed Army Institute of Research

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Toxicology in Vitro
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/J.TIV.2011.11.006
State	Published - Feb 1 2012
Externally published	Yes

Disciplines

Biochemistry

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@article{3144a6dd06944c95aa1fd5c79cb216de,

title = "Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis",

author = "Michael Costante and Lionel Biggemann and Yonas Alamneh and Iswarduth Soojhawon and Radley Short and Savita Nigam and Gregory Garcia and Doctor, \{Bhupendra P.\} and Manojkumar Valiyaveettil and Nambiar, \{Madhusoodana P.\}",

note = "Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bioscavenger, we evaluated the in vitro hydrolysis eff ...",

year = "2012",

month = feb,

day = "1",

doi = "10.1016/J.TIV.2011.11.006",

language = "American English",

volume = "26",

journal = "Toxicology in Vitro",

number = "1",

}

TY - JOUR

T1 - Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

AU - Costante, Michael

AU - Biggemann, Lionel

AU - Alamneh, Yonas

AU - Soojhawon, Iswarduth

AU - Short, Radley

AU - Nigam, Savita

AU - Garcia, Gregory

AU - Doctor, Bhupendra P.

AU - Valiyaveettil, Manojkumar

AU - Nambiar, Madhusoodana P.

N1 - Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bioscavenger, we evaluated the in vitro hydrolysis eff ...

PY - 2012/2/1

Y1 - 2012/2/1

UR - https://www.ncbi.nlm.nih.gov/pubmed/22120822

U2 - 10.1016/J.TIV.2011.11.006

DO - 10.1016/J.TIV.2011.11.006

M3 - Article

VL - 26

JO - Toxicology in Vitro

JF - Toxicology in Vitro

IS - 1

ER -

Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

Disciplines

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