Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

Xiao-Ping Xu; Jennifer S. Pollock; Miles A. Tanner; Paul R. Myers

doi:10.1016/S0008-6363(95)00117-4

Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

Xiao-Ping Xu
, Jennifer S. Pollock
, Miles A. Tanner
, Paul R. Myers

University of Missouri
Abbott Laboratories, Abbott Park, Chicago, IL 60064, USA

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Cardiovascular Research
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/S0008-6363(95)00117-4
State	Published - Dec 1 1995

Disciplines

Biochemistry
Biology
Endocrinology
Internal Medicine

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@article{dad861d7036041f4acebad10c1fb305d,

title = "Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells",

author = "Xiao-Ping Xu and Pollock, \{Jennifer S.\} and Tanner, \{Miles A.\} and Myers, \{Paul R.\}",

note = "Objective: Hypoxia significantly alters vascular tone in coronary resistance arterioles during prolonged ischemia, potentially through the modulation of endothelial cell metabolism as well as endothelial function. The objective of this study was to test the hypothesis that constitutive nitric oxide synthase (cNOS) is sensitive to oxygen tension and that hypoxia increases the activity of cNOS and nitric oxide production in the porcine coronary microcirculation.",

year = "1995",

month = dec,

day = "1",

doi = "10.1016/S0008-6363(95)00117-4",

language = "American English",

volume = "30",

journal = "Cardiovascular Research",

issn = "1755-3245",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

AU - Xu, Xiao-Ping

AU - Pollock, Jennifer S.

AU - Tanner, Miles A.

AU - Myers, Paul R.

N1 - Objective: Hypoxia significantly alters vascular tone in coronary resistance arterioles during prolonged ischemia, potentially through the modulation of endothelial cell metabolism as well as endothelial function. The objective of this study was to test the hypothesis that constitutive nitric oxide synthase (cNOS) is sensitive to oxygen tension and that hypoxia increases the activity of cNOS and nitric oxide production in the porcine coronary microcirculation.

PY - 1995/12/1

Y1 - 1995/12/1

UR - http://www.ncbi.nlm.nih.gov/pubmed/8746197

U2 - 10.1016/S0008-6363(95)00117-4

DO - 10.1016/S0008-6363(95)00117-4

M3 - Article

SN - 1755-3245

VL - 30

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 6

ER -

Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

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