Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell

Deepali K. Hattangadi; Gerald A. DeMasters; Teneille D. Walker; Kara R. Jones; Xu Di; Irene F. Newsham; David A. Gewirtz; Gerald A. Demasters

doi:10.1016/J.BCP.2004.06.033

Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell

Deepali K. Hattangadi
, Gerald A. DeMasters
, Teneille D. Walker
, Kara R. Jones
, Xu Di
, Irene F. Newsham
, David A. Gewirtz
, Gerald A. Demasters

Virginia Commonwealth University
School of Health Professions

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochemical Pharmacology
Volume	68
Issue number	9
DOIs	https://doi.org/10.1016/J.BCP.2004.06.033
State	Published - Nov 1 2004

Disciplines

Biology
Oncology

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10.1016/J.BCP.2004.06.033License: Unspecified

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@article{ca322e1006d64f6cbb5c326dbf7bcce0,

title = "Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell",

author = "Hattangadi, \{Deepali K.\} and DeMasters, \{Gerald A.\} and Walker, \{Teneille D.\} and Jones, \{Kara R.\} and Xu Di and Newsham, \{Irene F.\} and Gewirtz, \{David A.\} and Demasters, \{Gerald A.\}",

note = "The influence of p53 function and caspase 3 activity on the capacity of the antifolate, methotrexate, to promote senescence arrest and apoptotic cell death was investigated in breast tumor cells. In p53 wild-type, but caspase 3 deficient MCF-7 breast tumor cells, death of approximately 40\% of the cell population was observed immediately after acute exposure to 10 microM methotrexate (the IC80 value for a 2 h drug exposure).",

year = "2004",

month = nov,

day = "1",

doi = "10.1016/J.BCP.2004.06.033",

language = "American English",

volume = "68",

journal = "Biochemical Pharmacology",

number = "9",

}

TY - JOUR

T1 - Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell

AU - Hattangadi, Deepali K.

AU - DeMasters, Gerald A.

AU - Walker, Teneille D.

AU - Jones, Kara R.

AU - Di, Xu

AU - Newsham, Irene F.

AU - Gewirtz, David A.

AU - Demasters, Gerald A.

N1 - The influence of p53 function and caspase 3 activity on the capacity of the antifolate, methotrexate, to promote senescence arrest and apoptotic cell death was investigated in breast tumor cells. In p53 wild-type, but caspase 3 deficient MCF-7 breast tumor cells, death of approximately 40% of the cell population was observed immediately after acute exposure to 10 microM methotrexate (the IC80 value for a 2 h drug exposure).

PY - 2004/11/1

Y1 - 2004/11/1

UR - http://europepmc.org/abstract/MED/15450935

U2 - 10.1016/J.BCP.2004.06.033

DO - 10.1016/J.BCP.2004.06.033

M3 - Article

VL - 68

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 9

ER -

Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell

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