Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study

Hope Tobey; Tyler Lucas; Soumen Paul; Stuart S. Berr; Brittney Mehrkens; Per G Brolinson; Bradley G. Klein; Blaise M. Costa

doi:10.3233/JAD-191071

Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study

Hope Tobey
, Tyler Lucas
, Soumen Paul
, Stuart S. Berr
, Brittney Mehrkens
, Per G Brolinson
, Bradley G. Klein
, Blaise M. Costa

LewisGale Hospital Montgomery

HCA Healthcare
University of Virginia
Virginia–Maryland Regional College of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD.

Original language	American English
Journal	J Alzheimers Dis
Volume	74
Issue number	2
DOIs	https://doi.org/10.3233/JAD-191071
State	Published - 2020

Keywords

Alzheimer’s disease
TgF344-AD
cranial osteopathic manipulation
mechanical pressure
mechanoceutics

Disciplines

Medicine and Health Sciences
Nervous System Diseases
Osteopathic Medicine and Osteopathy

Access to Document

10.3233/JAD-191071License: Unspecified

Cite this

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title = "Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study",

abstract = " Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD. ",

keywords = "Alzheimer{\textquoteright}s disease, TgF344-AD, cranial osteopathic manipulation, mechanical pressure, mechanoceutics",

author = "Hope Tobey and Tyler Lucas and Soumen Paul and Berr, \{Stuart S.\} and Brittney Mehrkens and Brolinson, \{Per G\} and Klein, \{Bradley G.\} and Costa, \{Blaise M.\}",

year = "2020",

doi = "10.3233/JAD-191071",

language = "American English",

volume = "74",

journal = "J Alzheimers Dis",

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T1 - Mechanoceutics Alters Alzheimer's Disease Phenotypes in Transgenic Rats: A Pilot Study

AU - Tobey, Hope

AU - Lucas, Tyler

AU - Paul, Soumen

AU - Berr, Stuart S.

AU - Mehrkens, Brittney

AU - Brolinson, Per G

AU - Klein, Bradley G.

AU - Costa, Blaise M.

PY - 2020

Y1 - 2020

N2 - Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD.

AB - Current advancements in neurovascular biology relates a mechanoceutics treatment, known as cranial osteopathic manipulation (COM), Alzheimer's disease (AD). COM could be used as an evidence-based treatment strategy to improve the symptoms of AD if molecular mechanisms, which currently remain unclear, are elucidated. In the present pilot study, using transgenic rats, we have identified COM mediated changes in behavioral and biochemical parameters associated with AD phenotypes. We expect these changes may have functional implications that might account for improved clinical outcomes of COM treatment. Further investigations on COM will be helpful to establish an adjunct treatment for AD.

KW - Alzheimer’s disease

KW - TgF344-AD

KW - cranial osteopathic manipulation

KW - mechanical pressure

KW - mechanoceutics

U2 - 10.3233/JAD-191071

DO - 10.3233/JAD-191071

M3 - Article

VL - 74

JO - J Alzheimers Dis

JF - J Alzheimers Dis

IS - 2

ER -