Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.

Tim W Harrison; Pascal Chanez; Francesco Menzella; Giorgio Walter Canonica; Renaud Louis; Borja G Cosio; Njira L Lugogo; Arjun Mohan; Annie Burden; Lawrence McDermott; Esther Garcia Gil; James G Zangrilli; Wolfgang Pohl; Robert Voves; Maud Deschampheleire; Jean-Benoit Martinot; Rudi Peché; Kenneth Chapman; Amarjit Cheema; Delbert Dorscheid; J. Mark FitzGerald; Remi Gagnon; William Patrick Killorn; Ronald Olivenstein; George Philteos; Clare Ramsey; J. Douglass Rolf; Brandie Walker; Ole Hilberg; Tina Skjold; Ingrid Titlestad; Auli Hakulinen; Maritta Kilpeläinen; Michèle Ben Hayoun; Philippe Bonniaud; Arnaud Bourdin; Frédéric De Blay; Gaëtan Deslee; Gilles Devouassoux; Alain Didier; Youcef Douadi; Stéphanie Fry; Gilles Garcia; Pierre-Olivier Girodet; Christophe Leroyer; Antoine Magnan; Guillaume Mahay; Cécilia Nocent; Christophe Pison; Francis J. Averill

doi:10.1016/S2213-2600(20)30414-8

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.

Tim W Harrison
, Pascal Chanez
, Francesco Menzella
, Giorgio Walter Canonica
, Renaud Louis
, Borja G Cosio
, Njira L Lugogo
, Arjun Mohan
, Annie Burden
, Lawrence McDermott
, Esther Garcia Gil
, James G Zangrilli
, Wolfgang Pohl
, Robert Voves
, Maud Deschampheleire
, Jean-Benoit Martinot
, Rudi Peché
, Kenneth Chapman
, Amarjit Cheema
, Delbert Dorscheid

J. Mark FitzGerald, Remi Gagnon, William Patrick Killorn, Ronald Olivenstein, George Philteos, Clare Ramsey, J. Douglass Rolf, Brandie Walker, Ole Hilberg, Tina Skjold, Ingrid Titlestad, Auli Hakulinen, Maritta Kilpeläinen, Michèle Ben Hayoun, Philippe Bonniaud, Arnaud Bourdin, Frédéric De Blay, Gaëtan Deslee, Gilles Devouassoux, Alain Didier, Youcef Douadi, Stéphanie Fry, Gilles Garcia, Pierre-Olivier Girodet, Christophe Leroyer, Antoine Magnan, Guillaume Mahay, Cécilia Nocent, Christophe Pison, Francis J. Averill

National Institute for Health Research
Aix-Marseille University
Santa Maria Nuova Hospital
Humanitas University
University of Michigan
East Carolina University
AstraZeneca
University of Montpellier

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	The Lancet Respiratory Medicine
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/S2213-2600(20)30414-8
State	Published - Mar 1 2021

Disciplines

Medicine and Health Sciences
Internal Medicine

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Harrison, T. W., Chanez, P., Menzella, F., Canonica, G. W., Louis, R., Cosio, B. G., Lugogo, N. L., Mohan, A., Burden, A., McDermott, L., Gil, E. G., Zangrilli, J. G., Pohl, W., Voves, R., Deschampheleire, M., Martinot, J.-B., Peché, R., Chapman, K., Cheema, A., ... Averill, F. J. (2021). Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial. The Lancet Respiratory Medicine, 9(3). https://doi.org/10.1016/S2213-2600(20)30414-8

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial. / Harrison, Tim W; Chanez, Pascal; Menzella, Francesco et al.
In: The Lancet Respiratory Medicine, Vol. 9, No. 3, 01.03.2021.

Research output: Contribution to journal › Article › peer-review

Harrison, TW, Chanez, P, Menzella, F, Canonica, GW, Louis, R, Cosio, BG, Lugogo, NL, Mohan, A, Burden, A, McDermott, L, Gil, EG, Zangrilli, JG, Pohl, W, Voves, R, Deschampheleire, M, Martinot, J-B, Peché, R, Chapman, K, Cheema, A, Dorscheid, D, FitzGerald, JM, Gagnon, R, Killorn, WP, Olivenstein, R, Philteos, G, Ramsey, C, Rolf, JD, Walker, B, Hilberg, O, Skjold, T, Titlestad, I, Hakulinen, A, Kilpeläinen, M, Hayoun, MB, Bonniaud, P, Bourdin, A, De Blay, F, Deslee, G, Devouassoux, G, Didier, A, Douadi, Y, Fry, S, Garcia, G, Girodet, P-O, Leroyer, C, Magnan, A, Mahay, G, Nocent, C, Pison, C & Averill, FJ 2021, 'Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.', The Lancet Respiratory Medicine, vol. 9, no. 3. https://doi.org/10.1016/S2213-2600(20)30414-8

Harrison TW, Chanez P, Menzella F, Canonica GW, Louis R, Cosio BG et al. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial. The Lancet Respiratory Medicine. 2021 Mar 1;9(3). doi: 10.1016/S2213-2600(20)30414-8

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title = "Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.",

author = "Harrison, \{Tim W\} and Pascal Chanez and Francesco Menzella and Canonica, \{Giorgio Walter\} and Renaud Louis and Cosio, \{Borja G\} and Lugogo, \{Njira L\} and Arjun Mohan and Annie Burden and Lawrence McDermott and Gil, \{Esther Garcia\} and Zangrilli, \{James G\} and Wolfgang Pohl and Robert Voves and Maud Deschampheleire and Jean-Benoit Martinot and Rudi Pech{\'e} and Kenneth Chapman and Amarjit Cheema and Delbert Dorscheid and FitzGerald, \{J. Mark\} and Remi Gagnon and Killorn, \{William Patrick\} and Ronald Olivenstein and George Philteos and Clare Ramsey and Rolf, \{J. Douglass\} and Brandie Walker and Ole Hilberg and Tina Skjold and Ingrid Titlestad and Auli Hakulinen and Maritta Kilpel{\"a}inen and Hayoun, \{Mich{\`e}le Ben\} and Philippe Bonniaud and Arnaud Bourdin and \{De Blay\}, Fr{\'e}d{\'e}ric and Ga{\"e}tan Deslee and Gilles Devouassoux and Alain Didier and Youcef Douadi and St{\'e}phanie Fry and Gilles Garcia and Pierre-Olivier Girodet and Christophe Leroyer and Antoine Magnan and Guillaume Mahay and C{\'e}cilia Nocent and Christophe Pison and Averill, \{Francis J.\}",

note = "Background: ANDHI was done to assess the efficacy of benralizumab, including onset of effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and nasal polyposis symptoms. Methods: This phase 3b, randomised, double-blind, parallel-group, placebo-controlled ANDHI study was completed in adults (aged 18-75 years) with severe eosinophilic asthma with at least 2 exacerbations in the previous year, despite high-dose inhaled corticosteroid plus additional controllers, screening blood eosinophil counts of at least 150 cells per μL, and an Asthma Control Questionnaire 6 (ACQ-6) score of 1·5 or more.",

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T1 - Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.

AU - Harrison, Tim W

AU - Chanez, Pascal

AU - Menzella, Francesco

AU - Canonica, Giorgio Walter

AU - Louis, Renaud

AU - Cosio, Borja G

AU - Lugogo, Njira L

AU - Mohan, Arjun

AU - Burden, Annie

AU - McDermott, Lawrence

AU - Gil, Esther Garcia

AU - Zangrilli, James G

AU - Pohl, Wolfgang

AU - Voves, Robert

AU - Deschampheleire, Maud

AU - Martinot, Jean-Benoit

AU - Peché, Rudi

AU - Chapman, Kenneth

AU - Cheema, Amarjit

AU - Dorscheid, Delbert

AU - FitzGerald, J. Mark

AU - Gagnon, Remi

AU - Killorn, William Patrick

AU - Olivenstein, Ronald

AU - Philteos, George

AU - Ramsey, Clare

AU - Rolf, J. Douglass

AU - Walker, Brandie

AU - Hilberg, Ole

AU - Skjold, Tina

AU - Titlestad, Ingrid

AU - Hakulinen, Auli

AU - Kilpeläinen, Maritta

AU - Hayoun, Michèle Ben

AU - Bonniaud, Philippe

AU - Bourdin, Arnaud

AU - De Blay, Frédéric

AU - Deslee, Gaëtan

AU - Devouassoux, Gilles

AU - Didier, Alain

AU - Douadi, Youcef

AU - Fry, Stéphanie

AU - Garcia, Gilles

AU - Girodet, Pierre-Olivier

AU - Leroyer, Christophe

AU - Magnan, Antoine

AU - Mahay, Guillaume

AU - Nocent, Cécilia

AU - Pison, Christophe

AU - Averill, Francis J.

N1 - Background: ANDHI was done to assess the efficacy of benralizumab, including onset of effect and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and nasal polyposis symptoms. Methods: This phase 3b, randomised, double-blind, parallel-group, placebo-controlled ANDHI study was completed in adults (aged 18-75 years) with severe eosinophilic asthma with at least 2 exacerbations in the previous year, despite high-dose inhaled corticosteroid plus additional controllers, screening blood eosinophil counts of at least 150 cells per μL, and an Asthma Control Questionnaire 6 (ACQ-6) score of 1·5 or more.

PY - 2021/3/1

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UR - https://arizona.pure.elsevier.com/en/publications/onset-of-effect-and-impact-on-health-related-quality-of-life-exac

U2 - 10.1016/S2213-2600(20)30414-8

DO - 10.1016/S2213-2600(20)30414-8

M3 - Article

VL - 9

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

IS - 3

ER -

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.

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