Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection.

Matthew A. Carrigan; Alonso Ricardo; Darwin N. Ang; Steven A. Benner

doi:10.1021/BI049898L

Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection.

Matthew A. Carrigan
, Alonso Ricardo
, Darwin N. Ang
, Steven A. Benner

Foundation for Applied Molecular Evolution, Incorporated, Post Office Box 13174, Gainesville, Florida 32604, USA.

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Biochemistry
Volume	43
Issue number	36
DOIs	https://doi.org/10.1021/BI049898L
State	Published - Aug 18 2004

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Chemistry

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title = "Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection.",

author = "Carrigan, \{Matthew A.\} and Alonso Ricardo and Ang, \{Darwin N.\} and Benner, \{Steven A.\}",

note = "In vitro selections performed in the presence of Mg2+ generated DNA sequences capable of cleaving an internal ribonucleoside linkage. Several of these, surprisingly, displayed intermolecular catalysis and catalysis independent of Mg2+, features that the selection protocol was not explicitly designed to select. A detailed physical organic analysis was applied to one of these DNAzymes, termed 614.",

year = "2004",

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day = "18",

doi = "10.1021/BI049898L",

language = "American English",

volume = "43",

journal = "Biochemistry",

number = "36",

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T1 - Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection.

AU - Carrigan, Matthew A.

AU - Ricardo, Alonso

AU - Ang, Darwin N.

AU - Benner, Steven A.

N1 - In vitro selections performed in the presence of Mg2+ generated DNA sequences capable of cleaving an internal ribonucleoside linkage. Several of these, surprisingly, displayed intermolecular catalysis and catalysis independent of Mg2+, features that the selection protocol was not explicitly designed to select. A detailed physical organic analysis was applied to one of these DNAzymes, termed 614.

PY - 2004/8/18

Y1 - 2004/8/18

UR - https://pubs.acs.org/doi/10.1021/bi049898l

U2 - 10.1021/BI049898L

DO - 10.1021/BI049898L

M3 - Article

VL - 43

JO - Biochemistry

JF - Biochemistry

IS - 36

ER -

Quantitative analysis of a RNA-cleaving DNA catalyst obtained via in vitro selection.

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