Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)

Ruben Niesvizky; Paul G. Richardson; Andrew J. Yee; Ajay K Nooka; Marc S Raab; Kenneth H. Shain; Nashat Y. Gabrail; Jeffrey Matous; Amit B. Agarwal; James Hoffman; Sumit Madan; John M. Pagel; Jesus San Miguel; Philippe Moreau; Maria-Victoria Mateos; Thierry Facon; David Tamang; Simon S Jones; Robert J Markelewicz; Catherine Wheeler; Nikolaus S. Trede; Noopur Raje; Evangelos Terpos; William I. Bensinger

doi:10.1182/BLOOD.V128.22.3307.3307

Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)

Ruben Niesvizky
, Paul G. Richardson
, Andrew J. Yee
, Ajay K Nooka
, Marc S Raab
, Kenneth H. Shain
, Nashat Y. Gabrail
, Jeffrey Matous
, Amit B. Agarwal
, James Hoffman
, Sumit Madan
, John M. Pagel
, Jesus San Miguel
, Philippe Moreau
, Maria-Victoria Mateos
, Thierry Facon
, David Tamang
, Simon S Jones
, Robert J Markelewicz
, Catherine Wheeler

Nikolaus S. Trede, Noopur Raje, Evangelos Terpos, William I. Bensinger

Cornell University
Harvard University
Emory University
Heidelberg University
Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
Gabrail Cancer Center, Canton, OH
Colorado Blood Cancer Institute, Denver, CO
University of Arizona
University of Miami
University of Texas Health Science Center at San Antonio
Swedish Medical Center, Seattle, WA
Chartered Institute of Management Accountants
Department of Hematology, Nantes University Hospital, Nantes, France
Hematology, University Hospital of Salamanca-IBSAL, Salamanca, Spain
Maladies du Sang, Hôpital Claude Huriez, CHRU Lille, Lille, France
Acetylon Pharmaceuticals, Inc., Boston,
Acetylon Pharmaceuticals, Inc., Boston, MA
National and Kapodistrian University of Athens
Fred Hutchinson Cancer Research Center

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Blood
Volume	128
Issue number	22
DOIs	https://doi.org/10.1182/BLOOD.V128.22.3307.3307
State	Published - Dec 2 2016
Externally published	Yes

Disciplines

Medicine and Health Sciences
Internal Medicine

Access to Document

10.1182/BLOOD.V128.22.3307.3307License: Unspecified

Cite this

Niesvizky, R., Richardson, P. G., Yee, A. J., Nooka, A. K., Raab, M. S., Shain, K. H., Gabrail, N. Y., Matous, J., Agarwal, A. B., Hoffman, J., Madan, S., Pagel, J. M., San Miguel, J., Moreau, P., Mateos, M.-V., Facon, T., Tamang, D., Jones, S. S., Markelewicz, R. J., ... Bensinger, W. I. (2016). Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study). Blood, 128(22). https://doi.org/10.1182/BLOOD.V128.22.3307.3307

Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study). / Niesvizky, Ruben; Richardson, Paul G.; Yee, Andrew J. et al.
In: Blood, Vol. 128, No. 22, 02.12.2016.

Research output: Contribution to journal › Article › peer-review

Niesvizky, R, Richardson, PG, Yee, AJ, Nooka, AK, Raab, MS, Shain, KH, Gabrail, NY, Matous, J, Agarwal, AB, Hoffman, J, Madan, S, Pagel, JM, San Miguel, J, Moreau, P, Mateos, M-V, Facon, T, Tamang, D, Jones, SS, Markelewicz, RJ, Wheeler, C, Trede, NS, Raje, N, Terpos, E & Bensinger, WI 2016, 'Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)', Blood, vol. 128, no. 22. https://doi.org/10.1182/BLOOD.V128.22.3307.3307

Niesvizky R, Richardson PG, Yee AJ, Nooka AK, Raab MS, Shain KH et al. Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study). Blood. 2016 Dec 2;128(22). doi: 10.1182/BLOOD.V128.22.3307.3307

@article{10f1f99905214b2ab1e96b219c6ee0df,

title = "Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)",

author = "Ruben Niesvizky and Richardson, \{Paul G.\} and Yee, \{Andrew J.\} and Nooka, \{Ajay K\} and Raab, \{Marc S\} and Shain, \{Kenneth H.\} and Gabrail, \{Nashat Y.\} and Jeffrey Matous and Agarwal, \{Amit B.\} and James Hoffman and Sumit Madan and Pagel, \{John M.\} and \{San Miguel\}, Jesus and Philippe Moreau and Maria-Victoria Mateos and Thierry Facon and David Tamang and Jones, \{Simon S\} and Markelewicz, \{Robert J\} and Catherine Wheeler and Trede, \{Nikolaus S.\} and Noopur Raje and Evangelos Terpos and Bensinger, \{William I.\}",

note = "Ruben Niesvizky, Paul G. Richardson, Andrew J. Yee, Ajay K Nooka, Marc S Raab, Kenneth H. Shain, Nashat Y. Gabrail, Jeffrey Matous, Amit B. Agarwal, James Hoffman, Sumit Madan, John M. Pagel, Jesus San Miguel, Philippe Moreau, Maria-Victoria Mateos, Thierry Facon, David Tamang, Simon S Jones, Robert J Markelewicz, Catherine Wheeler, Nikolaus S.",

year = "2016",

month = dec,

day = "2",

doi = "10.1182/BLOOD.V128.22.3307.3307",

language = "American English",

volume = "128",

journal = "Blood",

publisher = "American Society of Hematology",

number = "22",

}

TY - JOUR

T1 - Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)

AU - Niesvizky, Ruben

AU - Richardson, Paul G.

AU - Yee, Andrew J.

AU - Nooka, Ajay K

AU - Raab, Marc S

AU - Shain, Kenneth H.

AU - Gabrail, Nashat Y.

AU - Matous, Jeffrey

AU - Agarwal, Amit B.

AU - Hoffman, James

AU - Madan, Sumit

AU - Pagel, John M.

AU - San Miguel, Jesus

AU - Moreau, Philippe

AU - Mateos, Maria-Victoria

AU - Facon, Thierry

AU - Tamang, David

AU - Jones, Simon S

AU - Markelewicz, Robert J

AU - Wheeler, Catherine

AU - Trede, Nikolaus S.

AU - Raje, Noopur

AU - Terpos, Evangelos

AU - Bensinger, William I.

N1 - Ruben Niesvizky, Paul G. Richardson, Andrew J. Yee, Ajay K Nooka, Marc S Raab, Kenneth H. Shain, Nashat Y. Gabrail, Jeffrey Matous, Amit B. Agarwal, James Hoffman, Sumit Madan, John M. Pagel, Jesus San Miguel, Philippe Moreau, Maria-Victoria Mateos, Thierry Facon, David Tamang, Simon S Jones, Robert J Markelewicz, Catherine Wheeler, Nikolaus S.

PY - 2016/12/2

Y1 - 2016/12/2

UR - https://ashpublications.org/blood/article/128/22/3307/98006/Selective-HDAC6-Inhibitor-ACY-241-an-Oral-Tablet

U2 - 10.1182/BLOOD.V128.22.3307.3307

DO - 10.1182/BLOOD.V128.22.3307.3307

M3 - Article

VL - 128

JO - Blood

JF - Blood

IS - 22

ER -

Selective HDAC6 Inhibitor ACY-241, an Oral Tablet, Combined with Pomalidomide and Dexamethasone: Safety and Efficacy of Escalation and Expansion Cohorts in Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma (ACE-MM-200 Study)

Disciplines

Access to Document

Other files and links

Cite this