The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells

Katlin Davitt; Blake D Babcock; Maly Fenelus; Chi Kong Poon; Abhishek Sarkar; Vincent Trivigno; Paul A Zolkind; Sheena M Matthew; Natalia Grin'kina; Zulfiya Orynbayeva; Mohammad F Shaikh; Victor Adler; Josef Michl; Ehsan Sarafraz-Yazdi; Matthew R Pincus; Wilbur B Bowne; Wilbur B Bowne

The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells

Katlin Davitt
, Blake D Babcock
, Maly Fenelus
, Chi Kong Poon
, Abhishek Sarkar
, Vincent Trivigno
, Paul A Zolkind
, Sheena M Matthew
, Natalia Grin'kina
, Zulfiya Orynbayeva
, Mohammad F Shaikh
, Victor Adler
, Josef Michl
, Ehsan Sarafraz-Yazdi
, Matthew R Pincus
, Wilbur B Bowne
, Wilbur B Bowne

Drexel University
SUNY Downstate Medical Center

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Annals of Clinical and Laboratory Science
Volume	44
Issue number	3
State	Published - Jun 20 2014
Externally published	Yes

Disciplines

Cell Biology

Cite this

Davitt, K., Babcock, B. D., Fenelus, M., Poon, C. K., Sarkar, A., Trivigno, V., Zolkind, P. A., Matthew, S. M., Grin'kina, N., Orynbayeva, Z., Shaikh, M. F., Adler, V., Michl, J., Sarafraz-Yazdi, E., Pincus, M. R., Bowne, W. B., & Bowne, W. B. (2014). The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells. Annals of Clinical and Laboratory Science, 44(3).

The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells. / Davitt, Katlin; Babcock, Blake D; Fenelus, Maly et al.
In: Annals of Clinical and Laboratory Science, Vol. 44, No. 3, 20.06.2014.

Research output: Contribution to journal › Article › peer-review

Davitt, K, Babcock, BD, Fenelus, M, Poon, CK, Sarkar, A, Trivigno, V, Zolkind, PA, Matthew, SM, Grin'kina, N, Orynbayeva, Z, Shaikh, MF, Adler, V, Michl, J, Sarafraz-Yazdi, E, Pincus, MR, Bowne, WB & Bowne, WB 2014, 'The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells', Annals of Clinical and Laboratory Science, vol. 44, no. 3.

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title = "The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells",

author = "Katlin Davitt and Babcock, \{Blake D\} and Maly Fenelus and Poon, \{Chi Kong\} and Abhishek Sarkar and Vincent Trivigno and Zolkind, \{Paul A\} and Matthew, \{Sheena M\} and Natalia Grin'kina and Zulfiya Orynbayeva and Shaikh, \{Mohammad F\} and Victor Adler and Josef Michl and Ehsan Sarafraz-Yazdi and Pincus, \{Matthew R\} and Bowne, \{Wilbur B\} and Bowne, \{Wilbur B\}",

note = "The results suggest that HDM-2 is expressed in the membranes of non-solid tissue tumor cells in addition to the membranes of solid tissue tumor cells. Since K-562 cells appear to be in the stem cell family, the results suggest that early developing tumor cells also express HDM-2 protein in their mem ...",

year = "2014",

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day = "20",

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volume = "44",

journal = "Annals of Clinical and Laboratory Science",

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T1 - The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells

AU - Davitt, Katlin

AU - Babcock, Blake D

AU - Fenelus, Maly

AU - Poon, Chi Kong

AU - Sarkar, Abhishek

AU - Trivigno, Vincent

AU - Zolkind, Paul A

AU - Matthew, Sheena M

AU - Grin'kina, Natalia

AU - Orynbayeva, Zulfiya

AU - Shaikh, Mohammad F

AU - Adler, Victor

AU - Michl, Josef

AU - Sarafraz-Yazdi, Ehsan

AU - Pincus, Matthew R

AU - Bowne, Wilbur B

N1 - The results suggest that HDM-2 is expressed in the membranes of non-solid tissue tumor cells in addition to the membranes of solid tissue tumor cells. Since K-562 cells appear to be in the stem cell family, the results suggest that early developing tumor cells also express HDM-2 protein in their mem ...

PY - 2014/6/20

Y1 - 2014/6/20

UR - https://pubmed.ncbi.nlm.nih.gov/25117093/

M3 - Article

SN - 1550-8080

VL - 44

JO - Annals of Clinical and Laboratory Science

JF - Annals of Clinical and Laboratory Science

IS - 3

ER -

The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells

Disciplines

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