Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

Minxian Wang; Ramesh Menon; Sanghamitra Mishra; Aniruddh P. Patel; Mark Chaffin; Deepak Tanneeru; Manjari Deshmukh; Oshin Mathew; Sanika Apte; Christina S. Devanboo; Sumathi Sundaram; Praveena Lakshmipathy; Sakthivel Murugan; Krishna Kumar Sharma; Karthikeyan Rajendran; Sam Santhosh; Rajesh Thachathodiyl; Hisham Ahamed; Aniketh Vijay Balegadde; Thomas Alexander; Krishnan Swaminathan; Rajeev Gupta; Ajit S. Mullasari; Alben Sigamani; Muralidhar Kanchi; Andrew S. Peterson; Adam S. Butterworth; John Danesh; Emanuele Di Angelantonio; Aliya Naheed; Michael Inouye; Rajiv Chowdhury; Ramprasad L. Vedam; Sekar Kathiresan; Ravi Gupta; Amit V. Khera

doi:10.1016/J.JACC.2020.06.024

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

Minxian Wang
, Ramesh Menon
, Sanghamitra Mishra
, Aniruddh P. Patel
, Mark Chaffin
, Deepak Tanneeru
, Manjari Deshmukh
, Oshin Mathew
, Sanika Apte
, Christina S. Devanboo
, Sumathi Sundaram
, Praveena Lakshmipathy
, Sakthivel Murugan
, Krishna Kumar Sharma
, Karthikeyan Rajendran
, Sam Santhosh
, Rajesh Thachathodiyl
, Hisham Ahamed
, Aniketh Vijay Balegadde
, Thomas Alexander

Krishnan Swaminathan, Rajeev Gupta, Ajit S. Mullasari, Alben Sigamani, Muralidhar Kanchi, Andrew S. Peterson, Adam S. Butterworth, John Danesh, Emanuele Di Angelantonio, Aliya Naheed, Michael Inouye, Rajiv Chowdhury, Ramprasad L. Vedam, Sekar Kathiresan, Ravi Gupta, Amit V. Khera

Broad Institute
MedGenome Labs Ltd., Bengaluru, India.
Harvard University
Eternal Heart Care Centre, Jaipur, India.
Narayana Health, Bengaluru, India.
Amrita Institute of Medical Sciences and Research Centre
Hospital Research Foundation
Madras Medical Mission
MedGenome Inc., Foster City, California.
National Institute for Health Research
International Centre for Diarrhoeal Disease Research, Bangladesh
Baker IDI Heart and Diabetes Institute
British Heart Foundation

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Journal of the American College of Cardiology
Volume	76
Issue number	6
DOIs	https://doi.org/10.1016/J.JACC.2020.06.024
State	Published - Aug 11 2020
Externally published	Yes

Disciplines

Medicine and Health Sciences
Internal Medicine

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Wang, M., Menon, R., Mishra, S., Patel, A. P., Chaffin, M., Tanneeru, D., Deshmukh, M., Mathew, O., Apte, S., Devanboo, C. S., Sundaram, S., Lakshmipathy, P., Murugan, S., Sharma, K. K., Rajendran, K., Santhosh, S., Thachathodiyl, R., Ahamed, H., Balegadde, A. V., ... Khera, A. V. (2020). Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians. Journal of the American College of Cardiology, 76(6). https://doi.org/10.1016/J.JACC.2020.06.024

Wang, M, Menon, R, Mishra, S, Patel, AP, Chaffin, M, Tanneeru, D, Deshmukh, M, Mathew, O, Apte, S, Devanboo, CS, Sundaram, S, Lakshmipathy, P, Murugan, S, Sharma, KK, Rajendran, K, Santhosh, S, Thachathodiyl, R, Ahamed, H, Balegadde, AV, Alexander, T, Swaminathan, K, Gupta, R, Mullasari, AS, Sigamani, A, Kanchi, M, Peterson, AS, Butterworth, AS, Danesh, J, Di Angelantonio, E, Naheed, A, Inouye, M, Chowdhury, R, Vedam, RL, Kathiresan, S, Gupta, R & Khera, AV 2020, 'Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians', Journal of the American College of Cardiology, vol. 76, no. 6. https://doi.org/10.1016/J.JACC.2020.06.024

@article{4eab1903374e4eb1aff63a34530f4eee,

title = "Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians",

author = "Minxian Wang and Ramesh Menon and Sanghamitra Mishra and Patel, \{Aniruddh P.\} and Mark Chaffin and Deepak Tanneeru and Manjari Deshmukh and Oshin Mathew and Sanika Apte and Devanboo, \{Christina S.\} and Sumathi Sundaram and Praveena Lakshmipathy and Sakthivel Murugan and Sharma, \{Krishna Kumar\} and Karthikeyan Rajendran and Sam Santhosh and Rajesh Thachathodiyl and Hisham Ahamed and Balegadde, \{Aniketh Vijay\} and Thomas Alexander and Krishnan Swaminathan and Rajeev Gupta and Mullasari, \{Ajit S.\} and Alben Sigamani and Muralidhar Kanchi and Peterson, \{Andrew S.\} and Butterworth, \{Adam S.\} and John Danesh and \{Di Angelantonio\}, Emanuele and Aliya Naheed and Michael Inouye and Rajiv Chowdhury and Vedam, \{Ramprasad L.\} and Sekar Kathiresan and Ravi Gupta and Khera, \{Amit V.\}",

note = "1 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts. 2 MedGenome Labs Ltd., Bengaluru, India. 3 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.",

year = "2020",

month = aug,

day = "11",

doi = "10.1016/J.JACC.2020.06.024",

language = "American English",

volume = "76",

journal = "Journal of the American College of Cardiology",

number = "6",

}

TY - JOUR

T1 - Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

AU - Wang, Minxian

AU - Menon, Ramesh

AU - Mishra, Sanghamitra

AU - Patel, Aniruddh P.

AU - Chaffin, Mark

AU - Tanneeru, Deepak

AU - Deshmukh, Manjari

AU - Mathew, Oshin

AU - Apte, Sanika

AU - Devanboo, Christina S.

AU - Sundaram, Sumathi

AU - Lakshmipathy, Praveena

AU - Murugan, Sakthivel

AU - Sharma, Krishna Kumar

AU - Rajendran, Karthikeyan

AU - Santhosh, Sam

AU - Thachathodiyl, Rajesh

AU - Ahamed, Hisham

AU - Balegadde, Aniketh Vijay

AU - Alexander, Thomas

AU - Swaminathan, Krishnan

AU - Gupta, Rajeev

AU - Mullasari, Ajit S.

AU - Sigamani, Alben

AU - Kanchi, Muralidhar

AU - Peterson, Andrew S.

AU - Butterworth, Adam S.

AU - Danesh, John

AU - Di Angelantonio, Emanuele

AU - Naheed, Aliya

AU - Inouye, Michael

AU - Chowdhury, Rajiv

AU - Vedam, Ramprasad L.

AU - Kathiresan, Sekar

AU - Gupta, Ravi

AU - Khera, Amit V.

N1 - 1 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts. 2 MedGenome Labs Ltd., Bengaluru, India. 3 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

PY - 2020/8/11

Y1 - 2020/8/11

UR - https://pubmed.ncbi.nlm.nih.gov/32762905/

U2 - 10.1016/J.JACC.2020.06.024

DO - 10.1016/J.JACC.2020.06.024

M3 - Article

VL - 76

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 6

ER -

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

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