Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

Azra Bihorac; Lakhmir S. Chawla; Andrew D. Shaw; Ali Al-Khafaji; Danielle L. Davison; George E. DeMuth; Robert Fitzgerald; Michelle Ng Gong; Derrel D. Graham; Kyle Gunnerson; Michael Heung; Saeed Jortani; Eric Kleerup; Jay L. Koyner; Kenneth Krell; Jennifer LeTourneau; Matthew Lissauer; James Miner; H. Bryant Nguyen; Luis M. Ortega; Wesley H. Self; Richard Sellman; Jing Shi; Joely Straseski; James E. Szalados; Scott T. Wilber; Michael G. Walker; Jason Wilson; Richard Wunderink; Janice L. Zimmerman; John A. Kellum

doi:10.1164/RCCM.201401-0077OC

Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

Azra Bihorac
, Lakhmir S. Chawla
, Andrew D. Shaw
, Ali Al-Khafaji
, Danielle L. Davison
, George E. DeMuth
, Robert Fitzgerald
, Michelle Ng Gong
, Derrel D. Graham
, Kyle Gunnerson
, Michael Heung
, Saeed Jortani
, Eric Kleerup
, Jay L. Koyner
, Kenneth Krell
, Jennifer LeTourneau
, Matthew Lissauer
, James Miner
, H. Bryant Nguyen
, Luis M. Ortega

Wesley H. Self, Richard Sellman, Jing Shi, Joely Straseski, James E. Szalados, Scott T. Wilber, Michael G. Walker, Jason Wilson, Richard Wunderink, Janice L. Zimmerman, John A. Kellum

University of Florida
George Washington University
Vanderbilt University
University of Pittsburgh
Stat-Tech Services
University of California, San Diego
Yeshiva University
Louisiana State University in Shreveport
Virginia Commonwealth University
University of Michigan
University of Louisville
University of California, Los Angeles
University of Chicago
Eastern Idaho Medical Consultants
Portland VA Medical Center
University of Maryland, Baltimore
Hennepin County Medical Center
Loma Linda University
Department of Nephrology, AGH Nephrology
International Heart Institute Montana
Statistical Consultant
University of Utah
University of Rochester
Summa Health System
University of South Florida
Northwestern University
Houston Methodist Hospital

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	189
Issue number	8
DOIs	https://doi.org/10.1164/RCCM.201401-0077OC
State	Published - Apr 15 2014
Externally published	Yes

Disciplines

Medicine and Health Sciences
Urology
Critical Care

Access to Document

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Cite this

Bihorac, A., Chawla, L. S., Shaw, A. D., Al-Khafaji, A., Davison, D. L., DeMuth, G. E., Fitzgerald, R., Gong, M. N., Graham, D. D., Gunnerson, K., Heung, M., Jortani, S., Kleerup, E., Koyner, J. L., Krell, K., LeTourneau, J., Lissauer, M., Miner, J., Nguyen, H. B., ... Kellum, J. A. (2014). Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication. American Journal of Respiratory and Critical Care Medicine, 189(8). https://doi.org/10.1164/RCCM.201401-0077OC

Bihorac, A, Chawla, LS, Shaw, AD, Al-Khafaji, A, Davison, DL, DeMuth, GE, Fitzgerald, R, Gong, MN, Graham, DD, Gunnerson, K, Heung, M, Jortani, S, Kleerup, E, Koyner, JL, Krell, K, LeTourneau, J, Lissauer, M, Miner, J, Nguyen, HB, Ortega, LM, Self, WH, Sellman, R, Shi, J, Straseski, J, Szalados, JE, Wilber, ST, Walker, MG, Wilson, J, Wunderink, R, Zimmerman, JL & Kellum, JA 2014, 'Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication', American Journal of Respiratory and Critical Care Medicine, vol. 189, no. 8. https://doi.org/10.1164/RCCM.201401-0077OC

@article{4ccf038f52e34b9e9384f88c92bd2b5f,

title = "Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication",

author = "Azra Bihorac and Chawla, \{Lakhmir S.\} and Shaw, \{Andrew D.\} and Ali Al-Khafaji and Davison, \{Danielle L.\} and DeMuth, \{George E.\} and Robert Fitzgerald and Gong, \{Michelle Ng\} and Graham, \{Derrel D.\} and Kyle Gunnerson and Michael Heung and Saeed Jortani and Eric Kleerup and Koyner, \{Jay L.\} and Kenneth Krell and Jennifer LeTourneau and Matthew Lissauer and James Miner and Nguyen, \{H. Bryant\} and Ortega, \{Luis M.\} and Self, \{Wesley H.\} and Richard Sellman and Jing Shi and Joely Straseski and Szalados, \{James E.\} and Wilber, \{Scott T.\} and Walker, \{Michael G.\} and Jason Wilson and Richard Wunderink and Zimmerman, \{Janice L.\} and Kellum, \{John A.\}",

note = "Rationale: We recently reported two novel biomarkers for acute kidney injury (AKI), tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), both related to G1 cell cycle arrest. Objectives: We now validate a clinical test for urinary [TIMP-2]d [IGFBP7] at a high-sensitivity cutoff greater than 0.3 for AKI risk stratification in a diverse population of critically ill patients.",

year = "2014",

month = apr,

day = "15",

doi = "10.1164/RCCM.201401-0077OC",

language = "American English",

volume = "189",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1535-4970",

publisher = "American Thoracic Society",

number = "8",

}

TY - JOUR

T1 - Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

AU - Bihorac, Azra

AU - Chawla, Lakhmir S.

AU - Shaw, Andrew D.

AU - Al-Khafaji, Ali

AU - Davison, Danielle L.

AU - DeMuth, George E.

AU - Fitzgerald, Robert

AU - Gong, Michelle Ng

AU - Graham, Derrel D.

AU - Gunnerson, Kyle

AU - Heung, Michael

AU - Jortani, Saeed

AU - Kleerup, Eric

AU - Koyner, Jay L.

AU - Krell, Kenneth

AU - LeTourneau, Jennifer

AU - Lissauer, Matthew

AU - Miner, James

AU - Nguyen, H. Bryant

AU - Ortega, Luis M.

AU - Self, Wesley H.

AU - Sellman, Richard

AU - Shi, Jing

AU - Straseski, Joely

AU - Szalados, James E.

AU - Wilber, Scott T.

AU - Walker, Michael G.

AU - Wilson, Jason

AU - Wunderink, Richard

AU - Zimmerman, Janice L.

AU - Kellum, John A.

N1 - Rationale: We recently reported two novel biomarkers for acute kidney injury (AKI), tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), both related to G1 cell cycle arrest. Objectives: We now validate a clinical test for urinary [TIMP-2]d [IGFBP7] at a high-sensitivity cutoff greater than 0.3 for AKI risk stratification in a diverse population of critically ill patients.

PY - 2014/4/15

Y1 - 2014/4/15

UR - https://einstein.pure.elsevier.com/en/publications/validation-of-cell-cycle-arrest-biomarkers-for-acute-kidney-injur-2

U2 - 10.1164/RCCM.201401-0077OC

DO - 10.1164/RCCM.201401-0077OC

M3 - Article

SN - 1535-4970

VL - 189

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 8

ER -

Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

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